Tesis

Perbandingan Efikasi Krim Urea 10% dengan Salap Vaselin Album pada Kulit Kering Pasien Kusta dalam Multi Drug Therapy Multibasiler = A Comparison of Urea 10% Cream vs Petrolatum Ointment on Leprosy Patient with Dry Skin on Multibacillary Multidrug Therapy

Latar belakang. Kulit kering merupakan keluhan yang sering dihadapi
pasien kusta, akibat kerusakan saraf otonom atau terapi yang didapat.
Tujuan. Membandingkan efikasi vaselin album dengan urea 10% sebagai
terapi kulit kering pasien kusta. Metode. Uji klinis acak tersamar ganda.
Subjek penelitian dibagi dua kelompok, yaitu kelompok urea 10% dan kelompok
vaselin album. Evaluasi dilakukan dalam 2 dan 4 minggu terapi dengan
mengukur transepidermal waterloss (TEWL) dan skor kulit kering (SRRC) pada
tungkai bawah. Hasil. Sebanyak 48 subjek penelitian (SP) mengikuti penelitian,
24 SP mendapat vaselin album dan 24 SP mendapat kr i m ur ea 10%. Ni l ai
TEWL pada kedua kel ompok menur un secar a ber makna sebel um
dan sesudah t er api . Penur unan t i dak ber beda ber makna ant ar a
kedua kel ompok, ( 6, 53 kel ompok vasel i n al bum ver sus 6, 45
kel ompok ur ea 10%) . Skor SRRC menur un secar a ber makna pada
kedua kel ompok sebel um dan sesuda h t er api 2 dan 4 mi nggu.
Penur unan skor SRRC t i dak ber beda ber makna ant ar a kedua
kel ompok, ( 2, 5 dan 3, 5 pada kel ompok vasel i n al bum ver sus 3 dan
3 pada kel ompok ur ea) . Kesimpulan. Kedua pel embab mampu
menurunkan TEWL dan SRRC pasi en kust a secara bermakna. Tetapi
perubahan nilai t ersebut tidak berbeda bermakna antara kel ompok
pengguna sal ap vaseli n album ataupun krim urea 10%.
Kata kunci. kusta; kulit kering; SRRC; TEWL.


Background. Dry skin is a common problem in leprosy patient, due to destruction
of autonom nerve or side effect of therapy. Aim. Compare the efficacy of urea
10% cream versus petrolatum ointment on leprosy patient with dry skin. Method.
Double blinded randomnized controlled study participant were divided into two
group, either received petrolatum ointment or urea 10% cream. Evaluation was
done after 2 and 4 weeks treatment by measuring transepidermal waterloss
(TEWL) and dry skin score (SRRC). Result. 48 participant enrolled in the study,
24 received urea 10% cream while 24 received petrolatum.TEWL value in both
groups were reduced significantly before and after medication. The difference was
not significant in both groups (6.53 in vaselin group and 6.45 in urea group).
SRRC score in both groups were reduced significantly before and after 2 and 4
weeks medication. The difference was also not significant in both groups (2,5 and
3,5 in vaselin group versus 3 and 3 in urea group). Conclusion. Both moisturizers
significantly reduce TEWL and dry skin score. There was no significantly
difference in reduction between vaselin album ointment and urea 10% cream.
Keywords.Dry skin; Leprosy; SRRC; TEWL