Tesis

Korelasi asupan dan kadar vitamin C, E dengan kadar isoprostan pekerja pabrik asbes = Correlation between Intakes and Level of Vitamin C and E and Isoprostane Level in Asbestos Factory Workers

Stress oksidatif merupakan dasar dari berbagai penyakit degeneratif dan kanker,
termasuk asbestosis dan mesotelioma. Kedua penyakit tersebut terjadi akibat
terinhalasinya serat asbes dalam jangka waktu lama dan jumlah pajanan yang
tinggi. Penelitian potong lintang di Sekretariat Buruh Karawang bulan Oktober
2014 dilakukan untuk menilai korelasi asupan dan kadar vitamin C, E dengan
kadar isoprostan. Lima puluh dua subjek yang bekerja di pabrik asbes selesai
mengikuti seluruh protokol penelitian. Hasil menunjukkan bahwa asupan vitamin
C dan kadar vitamin E berkorelasi negatif dengan kadar isoprostan, sedangkan
asupan vitamin E dan kadar vitamin C berkorelasi positif dengan kadar isoprostan
pekerja pabrik asbes. Korelasi tersebut secara statistik tidak bermakna. Penelitian
lanjut diperlukan untuk menilai kadar isoprostan secara series, sehingga bila ada
peningkatan yang signifikan dapat segera dikethui.
Kata Kunci:
Asbes, antioksidan, isoprostan, stres oksidatif, vitamin C, vitamin E


Oxidative stress is the base of various degenerative diseases and cancers,
including asbestosis and mesothelioma. Both of them occur due to prolonged
inhalation of asbestos fibers and high level of exposure. A cross-sectional study at
a labor secretariat in October 2014 was performed to assess the correlations
between intakes and levels of vitamin C and vitamin E and isoprostane level. Fifty
two subjects working at an asbestos factory finished the study. The result showed
that vitamin C intake and vitamin E level were negatively correlated with
isoprostane level. Meanwhile, vitamin E intake and vitamin C level were
positively correlated with isoprostane level in asbestos factory workers. These
correlations were statistically insignificant. Asbestos factory workers should be
educated to increase their intakes of vitamin C and vitamin E.
Keywords:
Asbestos, antioxidant, isoprostane, oxidative stress, vitamin C, vitamin E