Tesis

Hubungan antara Asupan Kalsium dengan Derajat Keparahan Stenosis pada Pasien Penyakit Jantung Koroner Laki-laki Dewasa = Association between Calcium Intake with Severity of Stenosis in Adult Male Coronary Artery Disease Patients

Penyakit jantung koroner (PJK) adalah penyebab kematian utama dengan
prevalensi di Indonesia 7,2%. Penelitian observasional memperlihatkan asupan
kalsium yang rendah berkorelasi dengan peningkatan beberapa faktor risiko dan
kejadian PJK, namun di lain pihak, didapatkan hubungan suplemen kalsium
dengan peningkatan morbiditas dan mortalitas akibat PJK. Penelitian ini bertujuan
untuk mengetahui hubungan antara asupan kalsium dengan derajat stenosis
berdasarkan skor Gensini. Metode penelitian adalah studi potong lintang pada 49
pasien PJK laki-laki berusia 19 sampai 65 tahun yang pertama kali angiografi
koroner di Pelayanan Jantung Terpadu (PJT) RSCM pada Juli sampai dengan
November 2014. Asupan kalsium berdasarkan kuesioner FFQ dan kalsium dan
albumin serum diperiksa sesaat sebelum dilakukan tindakan. Derajat stenosis
dinyatakan dengan skor Gensini. Pada penelitian didapatkan median asupan
kalsium 301,6 (93–1404) mg/hari dan tidak berkorelasi (r=0,13, p=0,37) dengan
kadar kalsium terkoreksi (rerata=8,8+0,4 mg/dL). Rerata skor Gensini didapatkan
sebesar 95,18 + 57,78. Asupan kalsium tidak berkorelasi dengan skor Gensini (r=0,04,
p=0,77). Penelitian ini menyimpulkan tidak terdapat korelasi yang bermakna antara asupan kalsium dengan derajat stenosis pada pasien PJK laki-laki dewasa,dengan kecenderungan korelasi negatif.



Coronary artery disease (CAD) is the leading cause of death, with its prevalence
in Indonesia 7.2%. Observational evidence suggested that calcium intake was
inversely associated with either some risks or event of CAD, but some others
found association between calcium supplements with increasing trend in
cardiovascular morbidity and mortality. This study proposed to investigate the
association between calcium intake and severity of coronary artery disease (CAD)
assessed by Gensini score. This cross sectional study enrolled 49 male patients
from 19 to 65 years old who underwent their first angiography at Holistic Cardiac
Care Centre Unit of Ciptomangunkusumo Hospital Indonesia from July to
November 2014. Subjects were assessed using food frequency questionnaires to
explore their historical intake of main food sources of calcium. Calcium and
albumin level were performed immediately before angiography. Severity of CAD
was assessed by Gensini Score. Association between calcium intake and Gensini
Score were analyzed. From the study we found median calcium intake was 301,6
(93 – 1404) mg/day and did not have correlation (r=0,13, p=0,37) with corrected
serum calcium (means=8,8+0,4 mg/dL). We found means of Gensini score was
95,18 +

57,78. We didn’t find any correlation between calcium intake with
Gensini score (r=-0,04, p=0,77). We conclude that there was no correlation
between calcium intake and severity of CAD, especially in male patients with
CAD with negative tendency.