Tesis

Awitan Dan Durasi Kerja Lidocaine Dalam Larutan One-Per-Mil Tumescent = The onset and duration of action of lidocaine in one-per-mil tumescent solution

Background: We aimed to profile the onset and duration of action of the lidocaine in
one-per-mil tumescent solution.

Methods: A controlled, prospective, and randomized triple blind study was conducted
on both hand of 12 healthy volunteers who were injected in two consecutive days in
his ring finger with either one-per-mil tumescent solution containing 0.2% lidocaine
(experimental finger) in one hand or 2% lidocaine (control finger) in the contralateral
hand. The onset and duration of action of lidocaine were measured over time by
Semmes-Weinstein and two-point discrimination test. The level of pain was evaluated
using visual analogue scale (VAS).

Results: The fastest onset of action in 2% lidocaine group was in the first minute
(range, minute 1 to 6). Average onset of action of one-per-mil tumescent solution was
4.67 minutes (± 2.53 minutes). Duration of action of 2% lidocaine was 95.58 minutes
(± 29.82 minutes), meanwhile the duration of one per-mil tumescent solution was 168.5
minutes (± 46.4 minutes) by 2PD test and 186.83 minutes (± 44.02 minutes) by SW
test. There were significant difference of the onset and duration of action of both
groups. Fingertip sensibility before and after the intervention did not change
significantly in both group.

Conclusion: This study shows that the onset and duration of action of lidocaine in the
one-per-mil solution injected in the finger using tumescent technique subsequently at
4.67 and 168.5 minutes in average. 0.2% lidocaine in one-per-mil tumescent solution
produced slower onset and longer duration of action compared to 2% lidocaine.


Pendahuluan: Tujuan studi ini adalah untuk mengetahui awitan dan durasi kerja
lidocaine dalam larutan one-per-mil tumescent.

Metode: Studi eksperimental dengan kontrol dan desain buta acak ganda (triple blind
study) dilakukan pada 12 subjek sehat yang diinjeksikan larutan one-per-mil tumescent
mengandung lidocaine 0,2% pada satu tangan atau lidocaine 2% pada tangan
kontralateral. Awitan dan durasi kerja lidocaine diukur berkala dengan uji sensoris
Semmes-Weinstein dan diskriminasi dua titik. Tingkat nyeri diukur dengan visual
analogue scale (VAS)

Hasil: Awitan tercepat pada grup lidocaine 2% tercatat pada menit ke 1 (rentang: menit
ke 1 hingga 6). Awitan rata-rata pada grup larutan one-per-mil tumescent adalah 4.67
menit (± 2.53 menit). Durasi kerja lidocaine 2% adalah 95.58 menit (± 29.82 menit),
sedangkan durasi kerja larutan one-per-mil tumescent adalah 168.5 menit (± 45.1
menit) dengan uji diskriminasi dua titik dan 186.83 menit (± 44.02 menit) dengan uji
sensoris Semmes-Weinstein. Terdapat perbedaan awitan dan durasi kerja yang
signifikan pada kedua grup. Tidak ditemukan perubahan sensibilitas ujung jari yang
signifikan pada kedua grup pada saat sebelum dan sesudah intervensi.

Kesimpulan: Studi ini menunjukkan awitan dan durasi kerja lidocaine dalam larutan
one-per-mil tumescent adalah rata-rata 4,67 dan 168,5 menit. Lidocaine 0,2% dalam
larutan one-per-mil tumescent menghasilkan awitan yang lebih lambat dan durasi kerja
yang lebih panjang dibandingkan dengan lidocaine 2%.