Tesis

Gambaran Fibrin Monomer pada Kehamilan = Fibrin monomer profile in pregnancy

Kehamilan diketahui sebagai salah satu faktor risiko utama terjadinya tromboemboli baik di arteri maupun vena, yang bisa meningkat sebanyak 4 sampai 5 kali. Venografi merupakan baku emas untuk diagnosis DVT namun karena invasif, tidak dilakukan pada wanita hamil. Thrombin Anti Thrombin complex (TAT) dan D-dimer (DD) adalah pemeriksaan yang secara klinis berguna untuk prediksi dan diagnosis trombosis. Namun kadar TAT dan DD akan meningkat dalam situasi yang bervariasi termasuk kehamilan. Penelitian ini bertujuan untuk mendapatkan gambaran kadar fibrin monomer pada kehamilan trimester 1, 2, dan 3. Terdapat 31 sampel masingmasing pada trimester 1, 2, dan 3. CV kontrol normal dan abnormal pemeriksaan fibrin monomer adalah 7.43% dan 3.51%. Kadar fibrin monomer menunjukkan distribusi tidak normal dengan nilai p = 0.001 ( 0.05), so data are presented as median values and value ranges. Based on the cut-off value of 6 µg/mL, then increased levels of fibrin monomer was only found in third trimester , which was 3.2%. Result: There were no significant differences between the first and the second trimester of pregnancy (p = 0.491). There were significant differences between the first and third trimester of pregnancy (p=0.004) as well as between the second and third of pregnancy (p=0.031). Thus, fibrin monomer level was relatively constant during pregnancy. Conclusion: fibrin monomer is relatively constant during pregnancy compared to D-dimer.
Keywords: activation of coagulation, fibrin monomer, first, second, and third trimester of pregnancy, and D-dimer