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Hubungan Peningkatan Kadar Eritropoetin Dengan Perbaikan Fungsi Jantung Pada Pasien Gagal Ginjal Yang Menjalani Transplantasi = The association between elevated levels of erythropoietin and Improvement of cardiac function on renal failure who underwent kidney transplantation.

Latar Belakang. Transplantasi ginjal dapat memperbaiki fungsi jantung. Penelitian eksperimental pada binatang membuktikan bahwa peningkatan kadar hormon eritropoetin memperbaiki fungsi jantung, namun secara klinis masih menjadi bahan perdebatan. Tujuan. Untuk menilai hubungan peningkatan kadar eritropoetin dengan perbaikan fungsi jantung pada pasien gagal ginjal yang menjalani transplantasi. Metoda Penelitian. Kohor prospektif pada pasien gagal ginjal yang menjalani transplantasi di RSCM. Jumlah subyek 21 orang yang dikumpulkan dalam kurun waktu Maret-September 2013. Pengambilan data ekokardiografi dan kadar eritropoetin dilakukan sebelum dan 3 bulan sesudah transplantasi ginjal. Analisis statistik dengan uji korelasi Pearson atau Spearman. Hasil: Penelitian ini menunjukkan peningkatan bermakna kadar eritropoetin 7,58 (2,56) mlU/ml menjadi 18,1(6,4) mlU/ml. Terdapat hubungan peningkatan kadar eritropoetin dengan LVEDD (r=-0,56 p0,05) Kesimpulan. Terdapat hubungan peningkatan kadar eritropoetin dengan perbaikan LVH, LVEDD pada pasien gagal ginjal yang menjalani transplantasi. Tidak ada hubungan peningkatan kadar eritropoetin dengan perbaikan LVEF.
Kata kunci. Transplantasi ginjal, eritropoetin, fungsi jantung.


Background. Kidney transplantation improved cardiac function. Based on animal trials, elevated levels of erythropoietin hormone can improved cardiac function, but in clinically still debate. Aim. To determine association between elevated levels of erythropoietin and improvement cardiac function on renal failure who underwent transplantation. Methods. Prospective cohort study on renal failure who underwent kidney transplantation at Cipto Mangunkusumo Hospital. The study include 21 subjects who collected it from Marct to September 2013. Data of echocardiography and erythropoietin level were collected at time prior to kidney transplantation and repeat 3 months there after. The association between elevated levels of erythropoietin and cardiac function was analyzed using Pearson correlation and Spearman test. Resulth. The study showed a significantly elevated levels of erythropoietin from 7,58 (2,56) to 18,1 (6,4) mlU/ml. There was statistically significant association between elevated levels of erythropoietin and LVEDD (r=-0,56 p