Skripsi

Jumlah Limfosit T-CD4+, T-CD8+, Rasio T-CD4+/T-CD8+ dan Hubungannya dengan Kadar Kolesterol Total Darah Pasien HIV (+). = Lymphocyte T-CD4+, T-CD8+, T-CD4+/ T-CD8+ Ratio and their Relation with Total Blood Cholesterol in HIV (+) Patient.

Skripsi ini berfokus pada jumlah limfosit T-CD4+, T-CD8+, rasio T-CD4+/T-CD8+ dan hubungannya dengan kadar kolesterol total darah pasien HIV (+). Penelitian ini menggunakan studi cross-sectional dengan data sekunder. Sebagian besar responden tergolong usia produktif dengan nilai median 27 tahun, 62,5% memiliki status gizi normal, 78,1 % memiliki sel T-CD4+ antara 200-500 /μL, 68,8% memiliki sel T-CD8+ >785 /μL, 96,9% memiliki rasio T-CD4+/T-CD8+ ≤1 dan kadar kolesterol total darah ≤200 mg/dL. Disimpulkan bahwa terdapat hubungan bermakna antara jumlah sel T-CD4+ dengan kadar kolesterol total darah (p=0,025). Tidak terdapat hubungan bermakna antara jumlah sel T-CD8+ dengan kadar kolesterol total darah (p=0,737), dan antara rasio T-CD4+/T-CD8+ dengan kadar kolesterol total darah (p=0,378). Penelitian ini menyarankan bahwa perlu dilakukan edukasi gizi pada pasien HIV/AIDS dan penelitian lebih lanjut dengan jumlah sampel yang lebih besar, sebaran responden cukup merata, dan data tambahan lain yang dapat mempengaruhi kadar kolesterol darah.
Kata kunci : Sel T-CD4+, sel T-CD8+, rasio T-CD4+/T-CD8+, kolesterol total darah.



The focus of this study was lymphocyte T-CD4+, T-CD8+, T-CD4+/T-CD8+ ratio and their relation with total blood cholesterol in HIV patient. This was a cross- sectional study using secondary data. Most of the respondents were at productive age with the median of age was 27, 62,5% had normal nutritional status, 78,1% had CD4+ count between 200-500 /μL, 68,8% had CD8+ count >785 /μL, 96,9% had T-CD4+/T-CD8+ ratio ≤1 and total blood cholesterol ≤200 mg/dL. We concluded that there was significant relationship between CD4+ count and total blood cholesterol (p=0,025) but there was no significant relationship between CD8+ count and total blood cholesterol (p=0,737), and between T-CD4+/T-CD8+ ratio and total blood cholesterol (p=0,378). This study suggests that nutritional education was needed and further study should be performed with bigger sample, normal distribution of respondent, and additional data about another factor that contribute to blood cholesterol.
Key words : T-CD4+, T-CD8+, T-CD4+/T-CD8+ ratio, total blood cholesterol.