Skripsi

Peran capsaicin dalam proses penyembuhan ulkus lambung tikus yang diberi paparan aspirin. = Effect of capsaicin in healing process of gastric ulcers induced by aspirin in rats.

Latar belakang Aspirin, salah satu dari obat antiinflamasi nonsteroid, menghambat pembentukan prostaglandin dengan menghambat siklooksigenase yang merupakan faktor yang berperan dalam integritas mukosa lambung. Aspirin umumnya dipakai dalam pencegahan infark miokard dan penyakit serebrovaskular iskemik namun aspirin sering menyebabkan tukak lambung. Capsaicin merupakan suatu senyawa yang ditemukan di cabai yang memiliki efek gastroprotektif. Tujuan penelitian ini untuk mengetahui efek pemberian capsaicin terhadap penyembuhan ulkus lambung yang diberi paparan aspirin. Metode P,enelitian ini menggunakan metode eksperimental. Subjek penelitian yaitu tikus Sprangue Dawley jantan berat badan 150-200 gram, usia 3 bulan. Ulkus lambung diinduksi dengan asam asetat dengan metode aplikasi serosal. Terdapat empat kelompok penelitian yaitu (I) kontrol, (2) yang diberi capsaicin, (3) aspirin, dan (4) aspirin dan capsaicin. Aspirin diberikan sebesar 100mg/kgBB, dan capsaicin diberikan sebesar 10mg/kgBB/hari. Paparan diberikan mulai hari ketiga sampai kesepuluh, kemudian luas ulkus diukur. Hasil Rata-rata luas ulkus kelompok kontrol yaitu 5.33 mm2, kelompok capsaicin sebesar 2 mm2, kelompok aspirin sebesar 57.67 mm2 dan kelompok aspirin & capsaicin sebesar 17 mm2. Hasil uji statistik: perbedaan bermakna terdapat antara kelompok kontrol dengan kelompok aspirin (p = 0.011), kelompok capsaicin dengan kelompok aspirin (p = 0.008) dan kelompok aspirin dengan kelompok aspirin dan capsaicin (p = 0.035). Kesimpulan Capsaicin berperan dalam proses penyembuhan ulkus lambung pada tikus yang diberi paparan aspirin. Hal ini menunjukkan babwa capsaicin berperan dalam proteksi mukosa lambung yang diberi intervensi paparan aspirin.
Kata Kunci: capsaicin, ulkus lambung, aspirin.



Background Aspirin, one of nonsteroid antiinflamatory drugs, inhibits prostaglandin production by inhibiting cyclooxygenase which is involved in maintaining gastric mucosa integrity. Aspirin is commonly used in prevention of myocardinal infarct and ischemic cerebrovascular disease but it often causes gastric ulcers. Capsaicin is a substance found in chili which has gastroprotective effects. The aim of this study is to know the effect of capsaicin in healing process of gastric ulcers induced by aspirin. Method This study was using experimental method. The subject was male Sprangue Dawley rats, weight 150-200 gram, 3 month old. Gastric ulcers were induced by acetic acid by serosal application method. There were four intervention group, (1) control, (2) capsaicin, (3) aspirin, and (4) aspirin & capsaicin. Aspirin was given at dose 100mg/BW and capsaicin was given at 10mg/BW/day. The intervention was given from the third day until the tenth day, then the ulcers were measured on the tenth day. Results The average score of ulcers area for control group, was 5.33 mm2, capsaicin group was 2 mm2, aspirin group was 57.67 mm2, and aspirin and capsaicin group was 17 mm2. Statistical analysis: significant mean difference were between control group and aspirin group and aspirin and capsaicin group (p=0.035). Conclusion Capsaicin is involved in healing process of gastric ulcers induced by aspirin in rats. This shows capsaicin is involved in protection of gastric mucosa which is ecposed aspirin. Keywords: capsaicin, gastric ulcers, aspirin.