Skripsi

Prevalensi Infeksi Staphylococcus epidermidis Berdasarkan Jenis Kelamin Pada Sampel Urin Dan Pola Kepekaannya Terhadap Antibiotika Cephalosporin Di Departemen Mikrobiologi Fakultas Kedokteran Universitas Indonesia Tahun 2006-2009. = Prevalence of Staphylococcus epidermidis in Urine Samples Relation to Sex and Its Pattern of Sensitivity to Cephalosporin at Department of Microbiology Faculty of Medicine University of Indonesia Year 2006-2009.

Informasi prevalensi S.epidermidis berdasarkan jenis kelamin pada sampel urin dan pola kepekaan bakteri terhadap antibiotika dibutuhkan untuk mengetahui angka persebaran infeksi S.epidermidis pada urin dan apakah antibiotika cephalosporin masih efektif sebagai terapi infeksi S.epidermidis. Penelitian menggunakan desain cross sectional dengan metode pengujian sampel menggunakan difusi cakram. Peneliti menggunakan seluruh sampel urin yang dikultur dan hasil uji kepekaan isolat S.epidermidis dari urin terhadap cephalosporin yaitu cefotiam, ceftriaxone, cefepime, dan cefditoren dari tahun 2006-2009 pada laboratorium mikrobiologi FKUI. Data Departemen Mikrobiologi FKUI menunjukkan hasil sebagai berikut, prevalensi S.epidermidis di sampel urin pada wanita tahun 2006-2009 adalah 6,84% dengan tiap tahunnya 10,66%, 11,70%, 4,97%, dan 1,74%. Prevalensi S.epidermidis di sampel urin pada pria tahun 2006-2009 adalah 4,29% dengan tiap tahunnya 6,5%, 4,26%, 4,42%, dan 1,74%. Diperoleh 90,5% isolat sensitif cefotiam dan cefepime, serta 71,4% isolat sensitif ceftriaxone pada tahun 2006. Pada tahun 2007, 78,6% isolat sensitif cefotiam, 42,9% isolat sensitif ceftriaxone, 71,4% isolat sensitif cefepime, dan 69,2% isolat sensitif cefditoren. Pada tahun 2008, 80% isolat sensitif cefotiam, 54,5% isolat sensitif ceftriaxone 90,9% isolat sensitif cefepime,dan 50% isolat sensitf cefditoren. Di tahun 2009, 100 % isolat sensitif cefotiam. Penelitian ini memperlihatkan bahwa prevalensi S.epidermidis pada urin wanita lebih tinggi dari pria dan prevalensi dari tahun 2006 hingga 2009 cenderung menurun. Pola kepekaan isolat S.epidermidis terhadap antibiotik golongan cephalosporin di 2006-2009 persentase sensitivitas masih lebih tinggi dibandingkan persentase resistensi dan persentase intermediet dan tidak ada perbedaan proporsi yang signifikan antara persentase resistensi, sensitivitas, dan intermedietnya.
Kata kunci : Cefotiam,ceftriaxone, cefepime, cefditoren, intermediet, kepekaan, resisten, sensitif.



Information about Prevalence of S.epidermidis in urine samples relation to sex and bacterial sensitivity patterns towards population number of infection S.epidermidis in urine and to know wheter cephalosporin is effective as S.epidermidis infection theurapy. The study is using the cross-sectional design and disk diffusin method in testing sample. Researchers use the entire culture urine sample and results of S.epidermidis sensitivity towards cephalosporin which is cefotiam, ceftriaxone, cefepime, and cefditoren in which using urine specimen from Departement of Microbiology Laboratory at FMUI from 2006-2009. Data of department of microbiological FMUI shows the following results. Prevalence S.epidermidis in urine in women from 2006-2009 is 6,84% per year 10,66%, 11,70%, 4,97%, and 1,74%. Prevalence S.epidermidis in urine in men from 2006-2009 is 4,29% per year 6,5%, 4,26%, 4,42 %, and 1,74%. There are 90,5% isolates were sensitive to cefotiam and cefepime, and 71,4% isolates were sensitive to ceftriaxon in 2006. In 2007, 78,6% isolates were sensitive to cefotiam, 42,9% isolates were sensitive to ceftriaxone, 71,4% isolates were sensitive to cefepime, and 69,2% isolates sensitive to cefditoren. In 2008, 80% isolates were sensitive to cefotiam, 54,5% isolates were sensitive to cetriaxone, 90,9% isolates were sensitive to cefepime, and 50% isolates were sensitive to cefditoren. While in the year 2009, 100% isolates were sensitive to cefotiam. This research shows that prevalence S.epidermidis in urine sample in women is higher than in men and revalence S.epidermidis in urine sample from 2006 to 2009 both in women and men are decreasing. Pattern of sensitivity of Staphylococcus epidermidis isolates from antibiotic cephalosporin in 2006 until 2009 is higher than pattern of resistance and intermediet and there are no diffrence proportion in pattern of resistance, sensitivity and intermediet.
Keywords : Cefotiam, ceftriaxone, cefepime, cefditoren, intermediet, sensitivity, resistant, and sensitive.