Skripsi

The Correlation Between Gleason Score and Prostate Specific Antigen (PSA) Level in Patients Diagnosed with Prostatic Adenocarcinoma at Department of Anatomical Pathology Cipto Mangunkusumo Hospital = Korelasi Antara Skor Gleason dengan Prostate Specific Antigen (PSA) pada pasien Adenokarsinoma Prostat di Departemen Patologi Anatomik RSCM.

Background: Prostatic adenocarcinoma is a malignancy that originates in prostate gland and is the second most frequent malignancies occur in men in Indonesia. Gleason score is used to classify the grading of the tumor and PSA is used as one of screening and diagnostic tools for prostate cancer. Aim: The aim of this research is to identify the correlation between Gleason score and PSA level in patients with prostate adenocarcinoma at Department of Anatomical Pathology Cipto Mangunkusumo Hospital. Method: The data of Gleason score and PSA level obtained from 77 samples taken from request forms from patients diagnosed with prostatic adenocarcinoma from 2011 to 2014 in the archieve of Department of Anatomical Pathology Cipto Mangunkusumo hostpital and the data was analyzed using Kendall Tau-b’s Rank Correlation in SPSS 20 program. Result: Most patient came with high Gleason Score (Gleason score >7). The minimum PSA level obtained from the archive in Department of Anatomical Pathology is 2.73 ng/ml and the highest value reached up to 7100 ng/ml. The average PSA level increased with the Gleason score. Gleason score 6, 7, 8, 9, and 10 has the average PSA level of 46.641 ng/ml, 63.935 ng/ml, 231.762 ng/ml, 542.146 ng/ml, and 1044.348 ng/ml respectively (p = 0.003, r = 0.254). Conclusion: There is statistically weak significant correlation between Gleason score and PSA level in patients with prostatic adenocarcinoma in Department of Anatomical Pathology Cipto Mangunkusumo Hospital. PSA increased as the Gleason score increase.
Keywords: Prostatic adenocarcinoma, Gleason score, Prostate Specific Antigen (PSA)


Latar Belakang: Adenokarsinoma prostat adalah keganasan yang berasal dari kelenjar prostat dan merupakan keganasan tersering kedua yang dialami pria di Indonesia. Skor Gleason digunakan untuk mengklasifikasi tingkat diferensiasi dari tumor sedangkan menghitung kadar PSA digunakan sebagai salah satu cara untuk mendiagnosis kanker prostat. Tujuan: Riset ini bertujuan untuk mengetahui ada tidaknya korelasi antara skor Gleason dengan kadar PSA pada pasien adenokarsinoma prostat di departemen Patologi Anatomik RSCM. Metode: Data mengenai skor Gleason dan level PSA dikumpulkan dari 77 sampel yang didapat dari form pemeriksaan hasil diagnosis dari pasien adenokarsinoma prostat dari tahun 2011 sampai dengan tahun 2014 di arsip Department Patologi Anatomik RSCM. Data diolah dengan menggunakan analisis uji korelasi Kendall Tau-b di program SPSS 20. Hasil: Sebagian besar pasien datang dengan skor Gleason yang sudah tinggi (skor Gleason >7). Nilai PSA terkecil yang didapat dari arsip departemen Patologi Anatomik sebesar 2,73 ng/ml sedangkan nilai tertinggi mencapai 7100 ng/ml. Nilai rata-rata PSA meningkat dengan meningkatnya skor Gleason. Rata-rata nilai PSA dari skor Gleason 6, 7, 8, 9, dan 10 adalah 46,641 ng/ml, 63,935 ng/ml, 231,762 ng/ml, 542,146 ng/ml, and 1044,348 ng/ml (p = 0,003, r = 0,254). Kesimpulan: Terdapat korelasi yang lemah antara skor Gleason dengan nilai PSA pada pasien adenokarsinoma prostat di Department Patologi Anatomik RSCM. Nilai PSA meningkat seiring meningkatnya skor Gleason.
Kata kunci: Adenokarsinoma prostat, skor Gleason, Prostate Specific Antigen (PSA)